Tetrazine-Responsive Self-immolative Linkers
نویسندگان
چکیده
منابع مشابه
Self-immolative polymers.
The investigation of synthetic polymers for biological applications is increasing as assembly techniques for generating welldefined macromolecules from artificial building blocks become more sophisticated. Synthesis techniques have now evolved such that a wide variety of functional groups can be tolerated by polymerization catalysts, and a fascinating and diverse range of macromolecular and pol...
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We report that aryl phthalate esters are robust self-immolative linkers. This linker is easy to conjugate and releases output phenols upon cleaving a fluoride-sensitive mask to yield a benign phthalic acid byproduct, making these linkers potentially useful as fluoride sensors and promising for use in biological and materials applications.
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Oxidation responsive polymers with triggered degradation pathways have been prepared via attachment of self-immolative moieties onto a hydrolytically unstable polyphosphazene backbone. After controlled main-chain growth, postpolymerization functionalization allows the preparation of hydrolytically stable poly(organo)phosphazenes decorated with a phenylboronic ester caging group. In oxidative en...
متن کاملProgrammable microcapsules from self-immolative polymers.
For the autonomous repair of damaged materials, microcapsules are needed that release their contents in response to a variety of physical and chemical phenomena, not just by direct mechanical rupture. Herein we report a general route to programmable microcapsules. This method creates core-shell microcapsules with polymeric shell walls composed of self-immolative polymer networks. The polymers i...
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A new self-immolative dendritic probe directly detects triacetone triperoxide through amplification of a single cleavage event initiated by one molecule of hydrogen peroxide into multiple-release of fluorogenic end-groups.
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2016
ISSN: 1439-4227
DOI: 10.1002/cbic.201600560